Share Email Print
cover

Proceedings Paper

Use of an optical clearing agent during noninvasive laser coagulation of the canine vas deferens, ex vivo and in vivo
Author(s): Christopher M. Cilip; Ashley E. Ross; Jonathan P. Jarow; Nathaniel M. Fried
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

Development of a noninvasive vasectomy technique may eliminate male fear of complications and result in a more popular procedure. This study explores application of an optical clearing agent (OCA) to the scrotal skin to reduce both the laser power necessary for successful noninvasive laser vasectomy and the probability of scrotal skin burns. A mixture of DMSO/glycerol was noninvasively delivered into the scrotal skin using a Madajet. Near-infrared laser radiation with a range of average powers (7.0-11.7 W) was delivered in conjunction with a range of cryogen spray cooling rates (0.20-0.33 Hz) to the skin surface in a canine model, ex vivo and in vivo. Burst pressure (BP) measurements were conducted to quantify the strength of vas closure. A 30-min application of the OCA improved skin transparency by 26 ± 5 %, reducing the average power necessary for successful noninvasive laser vasectomy from 9.2 W without OCA (BP = 291 ± 31 mmHg) to 7.0 W with OCA (BP = 292 ± 19 mmHg). Control studies without OCA at 7.0 W failed to coagulate the vas with burst pressures (82 ± 28 mmHg) significantly below typical ejaculation pressures (136 ± 29 mmHg). Application of an optical clearing agent reduced the laser power necessary for successful noninvasive thermal coagulation of the vas by approximately 25%. This technique may result in the use of a less expensive laser system and eliminate the formation of scrotal skin burns during the procedure.

Paper Details

Date Published: 2 March 2010
PDF: 6 pages
Proc. SPIE 7548, Photonic Therapeutics and Diagnostics VI, 75481C (2 March 2010); doi: 10.1117/12.840915
Show Author Affiliations
Christopher M. Cilip, The Univ. of North Carolina at Charlotte (United States)
Ashley E. Ross, Johns Hopkins Medical Institutions (United States)
Jonathan P. Jarow, Johns Hopkins Medical Institutions (United States)
Nathaniel M. Fried, The Univ. of North Carolina at Charlotte (United States)
Johns Hopkins Medical Institutions (United States)


Published in SPIE Proceedings Vol. 7548:
Photonic Therapeutics and Diagnostics VI
Anita Mahadevan-Jansen; E. Duco Jansen; Andreas Mandelis; Brian Jet-Fei Wong; Justus F. R. Ilgner; Nikiforos Kollias; Bernard Choi; Haishan Zeng; Henry Hirschberg; Steen J. Madsen; Kenton W. Gregory; Guillermo J. Tearney; Laura Marcu; Reza S. Malek, Editor(s)

© SPIE. Terms of Use
Back to Top