Share Email Print
cover

Proceedings Paper

Optofluidic biosensing for the study of disease at the molecular level
Author(s): Ian M. White
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

Despite decades of gains in biotechnology, currently much remains unknown about the molecular mechanisms of a number of deadly diseases. New tools are needed to speed discovery at the molecular level and to mitigate the complexity of studying the systems biology of disease. In the last decade, a number of advancements have been made in photonic biosensing aimed at developing a new generation of technologies for the study and early detection of disease. Label-free photonic biosensing techniques such as surface plasmon resonance imaging (SPRI), nanoporous silicon waveguides, interferometry, and optical resonators have achieved detection limits on par with conventional techniques while decreasing the size of the biosensing element and reducing the number of steps involved in the biosensing procedure. In addition, surface enhanced Raman spectroscopy (SERS) has been shown to detect molecules in extremely low numbers, even single molecules. In parallel to the development of a new generation of photonic biosensing techniques, advanced microfluidic technologies have emerged. The last decade has seen the development of automated micro-valves and micro-pumps, particle sorting, concentration gradient generation, and sample mixing. Also, photonic components, including waveguides and lenses, have been fabricated from soft-lithography materials. Synthesizing advanced microfluidic techniques with the new generation of photonic biosensing is likely to be the key to increasing throughput by increasing automation, decreasing equipment costs, and enabling multiplexing. This report will review examples of recent work in optofluidic biosensors and will discuss the opportunities for advancing research related to disease at the molecular level utilizing optofluidic biosensing technologies.

Paper Details

Date Published: 16 February 2010
PDF: 7 pages
Proc. SPIE 7606, Silicon Photonics V, 760609 (16 February 2010); doi: 10.1117/12.840877
Show Author Affiliations
Ian M. White, Univ. of Maryland, College Park (United States)


Published in SPIE Proceedings Vol. 7606:
Silicon Photonics V
Joel A. Kubby; Graham T. Reed, Editor(s)

© SPIE. Terms of Use
Back to Top