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Proceedings Paper

Localization of fluorescence marked prostate tumor with time- resolved diffuse optical tomography
Author(s): Lionel Hervé; Aurélie Laidevant; Ludovic Lecordier; Laurent Guyon; Mathieu Debourdeau; Jérôme Boutet; Jean-Marc Dinten
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Paper Abstract

To increase prostate cancer diagnosis sensibility, we propose to add an optical modality to an US biopsy tool to localize fluorophore marked tumors. Optical signals are acquired on a time-resolved acquisition chain composed by a 770 nm femtosecond laser source and a four channels TCSPC device. The fluorescence concentration is reconstructed by using intensity and mean time of flight acquired from each time-resolved source-detector signal. Validation experiments are performed on a phantom mimicking prostate both on its optical and ultrasound properties with 10 μmol/L ICG 1 cm deep double fluorescent inclusions to simulate marked tumors. An exhaustive search algorithm succeeded in reconstructing the two distinct fluorescence dots with correct locations.

Paper Details

Date Published: 23 February 2010
PDF: 9 pages
Proc. SPIE 7557, Multimodal Biomedical Imaging V, 75570F (23 February 2010); doi: 10.1117/12.840861
Show Author Affiliations
Lionel Hervé, CEA-LETI-MINATEC (France)
Aurélie Laidevant, CEA-LETI-MINATEC (France)
Ludovic Lecordier, CEA-LETI-MINATEC (France)
Laurent Guyon, CEA-LETI-MINATEC (France)
Mathieu Debourdeau, CEA-LETI-MINATEC (France)
Jérôme Boutet, CEA-LETI-MINATEC (France)
Jean-Marc Dinten, CEA-LETI-MINATEC (France)


Published in SPIE Proceedings Vol. 7557:
Multimodal Biomedical Imaging V
Fred S. Azar; Xavier Intes, Editor(s)

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