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Proceedings Paper

Rotational dynamics and polarization anisotropy of bound and unbound receptor-targeted contrast agents in cancerous and normal prostate tissues studied by time-resolved fluorescence spectroscopy
Author(s): Y. Pu; W. B. Wang; S. Achilefu; R. R. Alfano
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Paper Abstract

Temporal profiles of polarized fluorescence emitted from receptor-targeted contrast agents: Cybesin and Cytate, in prostate tissues were studied using ultrafast time-resolved spectroscopy. An analytical model was developed and used to investigate rotational dynamics and fluorescence polarization anisotropies of the contrast agents in prostate tissues from the measured data. The differences of rotational times and polarization anisotropies were observed for Cybesin (Cytate) in cancerous and normal prostate tissues, which reflect changes of micro-structures of cancerous and normal tissues, and their different bound affinity with contrast agents. This research may be used to develop better optical methods for in situ prostate cancer detection.

Paper Details

Date Published: 25 February 2010
PDF: 8 pages
Proc. SPIE 7561, Optical Biopsy VII, 75610A (25 February 2010); doi: 10.1117/12.840775
Show Author Affiliations
Y. Pu, The City College of New York (United States)
W. B. Wang, The City College of New York (United States)
S. Achilefu, Washington Univ. of School of Medicine (United States)
R. R. Alfano, The City College of New York (United States)

Published in SPIE Proceedings Vol. 7561:
Optical Biopsy VII
Robert R. Alfano, Editor(s)

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