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Proceedings Paper

Signal-to-noise analysis for 3D luminescence imaging of hypoxia in deep tissues
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Paper Abstract

We provide a detailed signal-to-noise analysis for 3D imaging of luminescence from a biomarker to detect hypoxic tumors in deep tissue. Preliminary studies on phantom tissues with inclusions and having homogeneous scattering and absorption coefficient of μs' ~ 15-20 cm-1 and μa ~ 2 cm-1 respectively, are reported as a function of oxygen tension, luminophore concentration, and tissue depth. The technique's sensitivity in terms of determination of spatial resolution is discussed.

Paper Details

Date Published: 23 February 2010
PDF: 6 pages
Proc. SPIE 7555, Advanced Biomedical and Clinical Diagnostic Systems VIII, 75551J (23 February 2010); doi: 10.1117/12.840736
Show Author Affiliations
Rajan Gurjar, Radiation Monitoring Devices, Inc. (United States)
Madhavi Seetamraju, Radiation Monitoring Devices, Inc. (United States)
David Wolf, Radiation Monitoring Devices, Inc. (United States)


Published in SPIE Proceedings Vol. 7555:
Advanced Biomedical and Clinical Diagnostic Systems VIII
Tuan Vo-Dinh; Warren S. Grundfest; Anita Mahadevan-Jansen, Editor(s)

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