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Proceedings Paper

A novel method for multiple lifetime recovery in time-domain optical imaging
Author(s): S. Fortier; G. Ma; M. Jean-Jacques
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Paper Abstract

A new multiple lifetime fitting algorithm is presented which deconvolves a time-domain system Instrument Response Function (IRF) from a measured Fluorescence Time Point Spread Function (FTPSF) prior to lifetime fitting. Deconvolution is followed by filtering, using a special case of the optimal Wiener filter, where the signal-to-noise ratio (SNR) in the spectral domain is evaluated empirically, and thus tuned with respect to each specific FTPSF-IRF combination at hand. Comparisons between the proposed deconvolution scheme and the classical Iterative Convolution (IC) scheme over a set of simulated and experimental data reveal that the proposed scheme typically exhibits order-of-magnitude performance gains (accuracy and efficiency combined) over the IC scheme in realistic conditions.

Paper Details

Date Published: 4 August 2009
PDF: 12 pages
Proc. SPIE 7386, Photonics North 2009, 73860G (4 August 2009); doi: 10.1117/12.839912
Show Author Affiliations
S. Fortier, ART Advanced Research Technologies, Inc. (Canada)
G. Ma, ART Advanced Research Technologies, Inc. (Canada)
M. Jean-Jacques, ART Advanced Research Technologies, Inc. (Canada)

Published in SPIE Proceedings Vol. 7386:
Photonics North 2009
Réal Vallée, Editor(s)

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