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Proceedings Paper

Directional assessment of fiber integrity in Q-ball imaging
Author(s): Klaus H. Fritzsche; Frederik B. Laun; Bram Stieltjes; Hans-Peter Meinzer
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Paper Abstract

Q-ball imaging (QBI) is a diffusion imaging technique that provides unique microstructural information and outperforms diffusion tensor imaging (DTI) in areas of fiber crossings. The generalized fractional anisotropy (GFA) is a widely accepted quantitative measure of fiber integrity for QBI. In this paper we demonstrate a major drawback of the GFA occuring in crossing fiber regions: the fiber integrity is heavily underestimated here. We present a new, directional anisotropy measure and compare it to the GFA using custom-designed fiber phantoms and Monte Carlo simulations. Furthermore, we present in-vivo data of the measure. With the expense of reduced CNR, the new measure allows a better quantification of fiber bundles in crossing regions and potentially yields additional information regarding non-dominant tracts within a voxel.

Paper Details

Date Published: 12 March 2010
PDF: 8 pages
Proc. SPIE 7623, Medical Imaging 2010: Image Processing, 76231G (12 March 2010); doi: 10.1117/12.839608
Show Author Affiliations
Klaus H. Fritzsche, German Cancer Research Ctr. (Germany)
Frederik B. Laun, German Cancer Research Ctr. (Germany)
Bram Stieltjes, German Cancer Research Ctr. (Germany)
Hans-Peter Meinzer, German Cancer Research Ctr. (Germany)

Published in SPIE Proceedings Vol. 7623:
Medical Imaging 2010: Image Processing
Benoit M. Dawant; David R. Haynor, Editor(s)

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