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Proceedings Paper

Fully automatic cardiac segmentation from 3D CTA data: a multi-atlas based approach
Author(s): Hortense A. Kirisli; Michiel Schaap; Stefan Klein; Lisan A. Neefjes; Annick C. Weustink; Theo Van Walsum; Wiro J. Niessen
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Paper Abstract

Computed tomography angiography (CTA), a non-invasive imaging technique, is becoming increasingly popular for cardiac examination, mainly due to its superior spatial resolution compared to MRI. This imaging modality is currently widely used for the diagnosis of coronary artery disease (CAD) but it is not commonly used for the diagnosis of ventricular and atrial function. In this paper, we present a fully automatic method for segmenting the whole heart (i.e. the outer surface of the myocardium) and cardiac chambers from CTA datasets. Cardiac chamber segmentation is particularly valuable for the extraction of ventricular and atrial functional information, such as stroke volume and ejection fraction. With our approach, we aim to improve the diagnosis of CAD by providing functional information extracted from the same CTA data, thus not requiring additional scanning. In addition, the whole heart segmentation method we propose can be used for visualization of the coronary arteries and for obtaining a region of interest for subsequent segmentation of the coronaries, ventricles and atria. Our approach is based on multi-atlas segmentation, and performed within a non-rigid registration framework. A leave-one-out quantitative validation was carried out on 8 images. The method showed a high accuracy, which is reflected in both a mean segmentation error of 1.05±1.30 mm and an average Dice coefficient of 0.93. The robustness of the method is demonstrated by successfully applying the method to 243 additional datasets, without any significant failure.

Paper Details

Date Published: 12 March 2010
PDF: 9 pages
Proc. SPIE 7623, Medical Imaging 2010: Image Processing, 762305 (12 March 2010); doi: 10.1117/12.838370
Show Author Affiliations
Hortense A. Kirisli, Erasmus MC (Netherlands)
Michiel Schaap, Erasmus MC (Netherlands)
Stefan Klein, Erasmus MC (Netherlands)
Lisan A. Neefjes, Erasmus MC (Netherlands)
Annick C. Weustink, Erasmus MC (Netherlands)
Theo Van Walsum, Erasmus MC (Netherlands)
Wiro J. Niessen, Erasmus MC (Netherlands)
Delft Univ. of Technology (Netherlands)


Published in SPIE Proceedings Vol. 7623:
Medical Imaging 2010: Image Processing
Benoit M. Dawant; David R. Haynor, Editor(s)

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