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Proceedings Paper

THz spectra of cortisone and the related medicine
Author(s): Shihua Ma; Min Ge; Guifeng Liu; Xiyu Song; Peng Zhang; Wenfeng Wang
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Paper Abstract

THz-TDS are used to study four kinds of drug: cortisone, hydrocortisone, prednisone and prednisolone. The THz spectra of them are obtained and analyzed from 0.2 - 1.6 THz. The experimental results shows the four samples have the different THz spectra. Cortisone has a peak at 1.5 THz and a broad absorption peak at 0.96 THz, while hydrocortisone has a weak absorption peak that lies at 1.27 THz. At the same time the prednisone has the stronger absorption peaks than the others, and its two peaks shows at 1.24 THz and 1.5 THz. Prednisolone has a weak broad peak at 1.43 THz. The results of the theoretical calculation were performed using Gaussian 03 software with Density Functional Theory at the basis set of 6-31+G (d, p). The theoretical vibrational frequencies are compared with the experimental results, and the deviations are discussed. The THz spectra of the medicine show THz technique may be help to distinguish some different chemical bond and functional group.

Paper Details

Date Published: 5 August 2009
PDF: 6 pages
Proc. SPIE 7385, International Symposium on Photoelectronic Detection and Imaging 2009: Terahertz and High Energy Radiation Detection Technologies and Applications, 738520 (5 August 2009); doi: 10.1117/12.836106
Show Author Affiliations
Shihua Ma, Shanghai Institute of Applied Physics (China)
Min Ge, Shanghai Institute of Applied Physics (China)
Guifeng Liu, Shanghai Institute of Applied Physics (China)
Xiyu Song, Shanghai Institute of Applied Physics (China)
Peng Zhang, Shanghai Institute of Applied Physics (China)
Wenfeng Wang, Shanghai Institute of Applied Physics (China)


Published in SPIE Proceedings Vol. 7385:
International Symposium on Photoelectronic Detection and Imaging 2009: Terahertz and High Energy Radiation Detection Technologies and Applications
X.-C. Zhang; James M. Ryan; Cun-lin Zhang; Chuan-xiang Tang, Editor(s)

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