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Proceedings Paper

A fiber-based, non-contact scheme for time-domain diffuse fluorescence tomography: methodology and simulative validation
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Paper Abstract

Non-contact scheme is prevalent to diffuse fluorescence tomography (FDT) since it facilitates instrumentation as well as simplifies experimental procedure. Although non-contact FDT generally uses CCD camera as detectors to achieve high throughput of data collection, a fiber-based implementation can make full use of well-established high-sensitive and time-resolved detection techniques. Therefore, a system that combines the fiber-based time-resolved detection and the non-contact geometry of optodes would be significantly attractive, which also means a more complex modeling of photon migration. This paper presents detailed computational aspects of the fiber-based non-contact DFT, including both the forward and inverse models. A pilot validation of the method is performed using simulated data for a two-dimensional case.

Paper Details

Date Published: 24 February 2010
PDF: 9 pages
Proc. SPIE 7557, Multimodal Biomedical Imaging V, 75570O (24 February 2010); doi: 10.1117/12.834836
Show Author Affiliations
Feng Gao, Tianjin Univ. (China)
Lab. d'Imagerie et de Neurosciences Cognitives, CNRS, Univ. de Strasbourg (France)
Meng Jing, Tianjin Univ. (China)
Jiao Li, Tianjin Univ. (China)
Farouk Nouizi, Lab. d'Imagerie et de Neurosciences Cognitives, CNRS, Univ. de Strasbourg (France)
Patrick Poulet, Lab. d'Imagerie et de Neurosciences Cognitives, CNRS, Univ. de Strasbourg (France)
Limin Zhang, Tianjin Univ. (China)
Huijuan Zhao, Tianjin Univ. (China)


Published in SPIE Proceedings Vol. 7557:
Multimodal Biomedical Imaging V
Fred S. Azar; Xavier Intes, Editor(s)

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