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Proceedings Paper

Dynamic retinal optical coherence microscopy without adaptive optics
Author(s): Rainer A. Leitgeb; Tilman Schmoll; Christoph Kolbitsch
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Paper Abstract

Novel CMOS detector technology allows for high-speed volumetric tissue imaging with Fourier domain optical coherence tomography. Acquisition speeds of 200kHz reveal comprehensive image details due to the virtual lack of motion artifacts. We applied this system to the retina and achieved high resolution imaging with 5μm x 3μm transverse and axial resolution. Such resolution allows observing microscopic details such as photoreceptor cone mosaic, nerve fiber bundles, and the capillary bed without applying adaptive optics instrumentation. Fast image series reveal perfusion dynamics of full retinal volumes and allow for tracking of individual photoreceptors to study their dynamics. We observed that for in-vivo imaging speed is crucial for reproducible maps of microscopic tissue details.

Paper Details

Date Published: 13 July 2009
PDF: 5 pages
Proc. SPIE 7372, Optical Coherence Tomography and Coherence Techniques IV, 737208 (13 July 2009); doi: 10.1117/12.831794
Show Author Affiliations
Rainer A. Leitgeb, Medical Univ. of Vienna (Austria)
Tilman Schmoll, Medical Univ. of Vienna (Austria)
Christoph Kolbitsch, Medical Univ. of Vienna (Austria)

Published in SPIE Proceedings Vol. 7372:
Optical Coherence Tomography and Coherence Techniques IV
Peter E. Andersen; Brett E. Bouma, Editor(s)

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