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Proceedings Paper

4D in vivo imaging of subpleural lung parenchyma by swept source optical coherence tomography
Author(s): S. Meissner; A. Tabuchi; M. Mertens; H. Homann; J. Walther; W. M. Kuebler; E. Koch
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Paper Abstract

In this feasibility study we present a method for 4D imaging of healthy and injured subpleural lung tissue in a mouse model. We used triggered swept source optical coherence tomography with an A-scan frequency of 20 kHz to image murine subpleural alveoli during the ventilation cycle. The data acquisition was gated to the pulmonary airway pressure to take one B-scan in each ventilation cycle for different pressure levels. The acquired B-scans were combined offline to one C-scan for each pressure level. Due to the high acquisition rate of the used optical coherence tomography system, we are also able to perform OCT Doppler imaging of the alveolar arterioles. We demonstrated that OCT is a useful tool to investigate the alveolar dynamics in spatial dimensions and to analyze the alveolar blood flow by using Doppler OCT.

Paper Details

Date Published: 13 July 2009
PDF: 6 pages
Proc. SPIE 7372, Optical Coherence Tomography and Coherence Techniques IV, 73720K (13 July 2009); doi: 10.1117/12.831790
Show Author Affiliations
S. Meissner, Univ. Hospital Carl Gustav Carus (Germany)
A. Tabuchi, St. Michael's Hospital (Canada)
M. Mertens, Charité Universitätsmedizin Berlin (Germany)
Freie Univ. Berlin (Germany)
H. Homann, Univ. Hospital Carl Gustav Carus (Germany)
J. Walther, Univ. Hospital Carl Gustav Carus (Germany)
W. M. Kuebler, St. Michael's Hospital (Canada)
Charité Universitätsmedizin Berlin (Germany)
E. Koch, Univ. Hospital Carl Gustav Carus (Germany)


Published in SPIE Proceedings Vol. 7372:
Optical Coherence Tomography and Coherence Techniques IV
Peter E. Andersen; Brett E. Bouma, Editor(s)

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