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Proceedings Paper

Enhancement of cancerous/normal tissue contrast via combined white light and fluorescence image processing: initial investigation ex vivo
Author(s): Angelos A. Kalitzeos; Azhar Zam; Florian Stelzle; Eckhart G. Hahn; Martin Raithel; Alexandre Douplik
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Paper Abstract

In the current study we try to optimise the cancerous/normal tissue contrast perception using white light and autofluorescence image processing. We deconvolved the RGB channels of both white light and autofluorescence images pixel by pixel and pointed out the best contrast enhancement technique, manipulating each channel seperately. By using false-color mapping according to a particular Look-Up Table, the borders between normal and cancerous area of the tissue are better delineated. Cancer tissue identification was confirmed by the histological examination that followed our investigation.

Paper Details

Date Published: 9 July 2009
PDF: 4 pages
Proc. SPIE 7371, Novel Optical Instrumentation for Biomedical Applications IV, 73710N (9 July 2009); doi: 10.1117/12.831771
Show Author Affiliations
Angelos A. Kalitzeos, Friedrich-Alexander Univ. of Erlangen-Nuremberg (Germany)
Azhar Zam, Friedrich-Alexander Univ. of Erlangen-Nuremberg (Germany)
Florian Stelzle, Erlangen Univ. Hospital (Germany)
Friedrich-Alexander Univ. of Erlangen-Nuremberg (Germany)
Eckhart G. Hahn, Erlangen Univ. Hospital (Germany)
Friedrich-Alexander Univ. of Erlangen-Nuremberg (Germany)
Martin Raithel, Erlangen Univ. Hospital (Germany)
Friedrich-Alexander Univ. of Erlangen-Nuremberg (Germany)
Alexandre Douplik, Friedrich-Alexander Univ. of Erlangen-Nuremberg (Germany)


Published in SPIE Proceedings Vol. 7371:
Novel Optical Instrumentation for Biomedical Applications IV
Christian D. Depeursinge; I. Alex Vitkin, Editor(s)

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