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Proceedings Paper

Effects of a finite spectral bandwidth light source in time-resolved diffuse spectroscopy
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Paper Abstract

We discuss the spectral distortions occurring when time-resolved diffuse spectroscopy is performed illuminating with a spectrally wide source. We show that the spectral region within the source bandwidth that exhibits the lowest absorption will dominate the resulting time-resolved curve, leading to significant distortions on the retrieved absorption spectrum (including shifts in peak positions). Due to the nonlinear behavior of the light attenuation due to absorption, this effect becomes more pronounced when including longer and longer photon path lengths. First, a theoretical treatment of the problem is given and then the distortion is described by timeresolved reflectance simulations and experimental measurements of lipid and water samples. Finally, a spectrally constrained data analysis is proposed to overcome the distortion and improve the accuracy of the estimation of chromophore concentrations from absorption spectra. Measurements on a lipid sample show a reduction of the error from 30% to 6%.

Paper Details

Date Published: 10 July 2009
PDF: 6 pages
Proc. SPIE 7369, Diffuse Optical Imaging II, 73690V (10 July 2009); doi: 10.1117/12.831695
Show Author Affiliations
Andrea Farina, Istituto Italiano di Tecnologia , ULTRAS, INFM, CNR and IFN-CNR, Politecnico di Milano (Italy)
Andrea Bassi, Istituto Italiano di Tecnologia , ULTRAS, INFM, CNR and IFN-CNR, Politecnico di Milano (Italy)
Paola Taroni, Istituto Italiano di Tecnologia , ULTRAS, INFM, CNR and IFN-CNR, Politecnico di Milano (Italy)
Daniela Comelli, Istituto Italiano di Tecnologia , ULTRAS, INFM, CNR and IFN-CNR, Politecnico di Milano (Italy)
Lorenzo Spinelli, Istituto Italiano di Tecnologia , ULTRAS, INFM, CNR and IFN-CNR, Politecnico di Milano (Italy)
Rinaldo Cubeddu, Istituto Italiano di Tecnologia , ULTRAS, INFM, CNR and IFN-CNR, Politecnico di Milano (Italy)
Antonio Pifferi, Istituto Italiano di Tecnologia , ULTRAS, INFM, CNR and IFN-CNR, Politecnico di Milano (Italy)


Published in SPIE Proceedings Vol. 7369:
Diffuse Optical Imaging II
Rinaldo Cubeddu; Andreas H. Hielscher, Editor(s)

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