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Proceedings Paper

Tomography of brain activation using a time-gated camera
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Paper Abstract

We propose a system for 3D tomography using a single pulsed source and a time-gated camera for functional imaging studies. Reconstructions were based on a linear model based on small perturbation assumption, applying Tikhonov regularization. This approach was tested against simulations, demonstrating both detection and localization capabilities. Preliminary measurements on realistic inhomogeneous phantoms showed good detection sensibility, even for a low optical contrast, but poorer localization properties, possibly due to the still low SNR of the system. Finally, an initial in vivo test on a motor cortex activation paradigm is presented.

Paper Details

Date Published: 10 July 2009
PDF: 5 pages
Proc. SPIE 7369, Diffuse Optical Imaging II, 73690R (10 July 2009); doi: 10.1117/12.831683
Show Author Affiliations
Antonio Pifferi, National Lab. for Ultrafast and Ultraintense Optical Science, CNR (Italy)
Istituto Italiano di Tecnologia, Politecnico di Milano (Italy)
Qing Zhao, Istituto Italiano di Tecnologia (Italy)
Lorenzo Spinelli, Istituto di Fotonica e Nanotecnologie, CNR (Italy)
Andrea Bassi, National Lab. for Ultrafast and Ultraintense Optical Science, CNR (Italy)
Politecnico di Milano (Italy)
Gianluca Valentini, Politecnico di Milano (Italy)
Davide Contini, Istituto Italiano di Tecnologia (Italy)
Politecnico di Milano (Italy)
Alessandro Torricelli, Istituto Italiano di Tecnologia (Italy)
Politecnico di Milano (Italy)
Rinaldo Cubeddu, National Lab. for Ultrafast and Ultraintense Optical Science, CNR (Italy)
Istituto Italiano di Tecnologia (Italy)
Politecnico di Milano (Italy)


Published in SPIE Proceedings Vol. 7369:
Diffuse Optical Imaging II
Rinaldo Cubeddu; Andreas H. Hielscher, Editor(s)

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