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Proceedings Paper

Reconstruction of fluorophore distribution for fluorescence diffuse tomography based on hybrid model
Author(s): Ilya Fiks; Mikhail Kirillin; Ekaterina Sergeeva; Mikhail Kleshnin; Ilya Turchin
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Paper Abstract

We propose a novel method for reconstruction of fluorophore spatial distribution in a highly scattering object imaged by means of fluorescence diffuse tomography. The method is based on algebraic reconstruction principle combined with a new theoretical model of light propagation in biotissues and Monte Carlo simulations. Monte Carlo simulations are also implemented for initial data calculations in approbation of the method. The reconstruction method was tested both for simulated and experimental initial data. We demonstrate that the method provides determination of center position of fluorescent inclusion in transversal direction with the accuracy of 1 mm, in-depth direction with the accuracy of 1.5 mm and determination of size of fluorescent inclusion with the accuracy of 1.5 mm.

Paper Details

Date Published: 9 July 2009
PDF: 7 pages
Proc. SPIE 7369, Diffuse Optical Imaging II, 73690B (9 July 2009); doi: 10.1117/12.831679
Show Author Affiliations
Ilya Fiks, Institute of Applied Physics (Russian Federation)
Mikhail Kirillin, Institute of Applied Physics (Russian Federation)
Ekaterina Sergeeva, Institute of Applied Physics (Russian Federation)
Mikhail Kleshnin, Institute of Applied Physics (Russian Federation)
Ilya Turchin, Institute of Applied Physics (Russian Federation)


Published in SPIE Proceedings Vol. 7369:
Diffuse Optical Imaging II
Rinaldo Cubeddu; Andreas H. Hielscher, Editor(s)

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