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Proceedings Paper

Effect of source decay in bioluminescence tomography: a phantom study
Author(s): Han Yan; Mehmet B. Unlu; Orhan Nalcioglu; Gultekin Gulsen
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Paper Abstract

Recent studies in bioluminescence tomography have been mainly focusing on the ill-posedness and non-uniqueness nature of the problem. In this paper, we demonstrate the significance of the effect of bioluminescence source decay on the reconstruction results with both simulations and phantom studies. Time variation of the bioluminescence source can cause artifacts in the tomographic images. The results show that source dynamic information is pivotal for accurate reconstruction when the decay half-life is comparable to the duration of the data acquisition.

Paper Details

Date Published: 9 July 2009
PDF: 6 pages
Proc. SPIE 7369, Diffuse Optical Imaging II, 73691O (9 July 2009); doi: 10.1117/12.831646
Show Author Affiliations
Han Yan, Ctr. for Functional Onco-Imaging, Univ. of California, Irvine (United States)
Mehmet B. Unlu, Ctr. for Functional Onco-Imaging, Univ. of California, Irvine (United States)
Orhan Nalcioglu, Ctr. for Functional Onco-Imaging, Univ. of California, Irvine (United States)
Gultekin Gulsen, Ctr. for Functional Onco-Imaging, Univ. of California, Irvine (United States)


Published in SPIE Proceedings Vol. 7369:
Diffuse Optical Imaging II
Rinaldo Cubeddu; Andreas H. Hielscher, Editor(s)

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