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Proceedings Paper

The implementation of an isotope-edited internal standard for quantification of lowest drug concentrations using surface enhanced Raman spectroscopy (SERS) in a lab on a chip device
Author(s): Anne März; Petra Rösch; Thomas Henkel; Jürgen Popp
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Paper Abstract

The application of surface enhanced Raman spectroscopy in combination with a microfluidic device and an isotopeedited internal standard seems to be a promising way for a new approach for quantitative SERS measurements. An innovative lab on a chip system offers the possibility for reproducible, quantitative online SERS measurements based on the application of isotope labelled internal standards and liquid/liquid segmented flow based flow-through Raman detection. Errors caused by the used method can be compensated by using an internal standard.

Paper Details

Date Published: 8 July 2009
PDF: 7 pages
Proc. SPIE 7368, Clinical and Biomedical Spectroscopy, 73680R (8 July 2009); doi: 10.1117/12.831619
Show Author Affiliations
Anne März, Friedrich-Schiller-Univ. Jena (Germany)
Petra Rösch, Friedrich-Schiller-Univ. Jena (Germany)
Thomas Henkel, Institute of Photonic Technology (Germany)
Jürgen Popp, Friedrich-Schiller-Univ. Jena (Germany)
Institute of Photonic Technology (Germany)


Published in SPIE Proceedings Vol. 7368:
Clinical and Biomedical Spectroscopy
Irene Georgakoudi; Jürgen Popp; Katarina Svanberg, Editor(s)

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