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Proceedings Paper

Myosin helical pitch angle as a quantitative imaging biomarker for characterization of cardiac programming in fetal growth restriction measured by polarization second harmonic microscopy
Author(s): I. Amat-Roldan; S, Psilodimitrakopoulos; E, Eixarch; I. Torre; B. Wotjas; F. Crispi; F. Figueras; D, Artigas; P. Loza-Alvarez; E, Gratacos
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Paper Abstract

Fetal growth restriction (FGR) has recently shown a strong association with cardiac programming which predisposes to cardiovascular mortality in adulthood. Polarization Second Harmonic Microscopy can quantify molecular architecture changes with high sensitivity in cardiac myofibrils. In this work, we use myosin helical pitch angle as an example to quantify such alterations related to this high risk population. Importantly, this shows a potential use of the technique as an early diagnostic tool and an alternative method to understand pathophysiological processes.

Paper Details

Date Published: 1 July 2009
PDF: 7 pages
Proc. SPIE 7367, Advanced Microscopy Techniques, 73670O (1 July 2009); doi: 10.1117/12.831481
Show Author Affiliations
I. Amat-Roldan, Hospital Clinic-IDIBAPS and CIBER-ER (Spain)
ICFO - Instituto de Ciencias Fotónicas (Spain)
S, Psilodimitrakopoulos, ICFO - Instituto de Ciencias Fotónicas (Spain)
E, Eixarch, Hospital Clinic-IDIBAPS and CIBER-ER (Spain)
I. Torre, Hospital Clinic-IDIBAPS and CIBER-ER (Spain)
B. Wotjas, Hospital Clinic-IDIBAPS and CIBER-ER (Spain)
F. Crispi, Hospital Clinic-IDIBAPS and CIBER-ER (Spain)
F. Figueras, Hospital Clinic-IDIBAPS and CIBER-ER (Spain)
D, Artigas, ICFO - Instituto de Ciencias Fotónicas (Spain)
P. Loza-Alvarez, ICFO - Instituto de Ciencias Fotónicas (Spain)
E, Gratacos, Hospital Clinic-IDIBAPS and CIBER-ER (Spain)


Published in SPIE Proceedings Vol. 7367:
Advanced Microscopy Techniques
Paul J. Campagnola; Ernst H. K. Stelzer; Gert von Bally, Editor(s)

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