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Proceedings Paper

Topology, dynamics, and control in cortical blood flow elucidated with optical techniques
Author(s): Philbert S. Tsai; Pablo Blinder; Patrick Drew; Jonathan Driscoll; Diana Jeong; John P. Kaufhold; Andy Shih; Ilya Valmianski; David Kleinfeld
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Paper Abstract

Blood is a limited resource that supplies neurons and glia with nutriments. How is blood distributed both in a fail-safe way and in response to changing metabolic loads? We examine this issue in rodent cortex. First, in terms of topology, all-optical histology is used to reconstruct the vasculature network. Second, in terms of dynamics, the flux of blood cells in individual vessels is measured in response to neuronal activation and/or the perturbation of flow of a targeted vessel via plasma-mediated ablation. Lastly, in terms of control, optical indicators of neurovascular signaling molecules that alter vessel diameter are measured.

Paper Details

Date Published: 21 August 2009
PDF: 4 pages
Proc. SPIE 7397, Biosensing II, 739718 (21 August 2009); doi: 10.1117/12.829588
Show Author Affiliations
Philbert S. Tsai, Univ. of California, San Diego (United States)
Pablo Blinder, Univ. of California, San Diego (United States)
Patrick Drew, Univ. of California, San Diego (United States)
Jonathan Driscoll, Univ. of California, San Diego (United States)
Diana Jeong, Univ. of California, San Diego (United States)
John P. Kaufhold, SAIC (United States)
Andy Shih, Univ. of California, San Diego (United States)
Ilya Valmianski, Univ. of California, San Diego (United States)
David Kleinfeld, Univ. of California, San Diego (United States)


Published in SPIE Proceedings Vol. 7397:
Biosensing II
Manijeh Razeghi; Hooman Mohseni, Editor(s)

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