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Proceedings Paper

Nanotechnology-based combination therapy improves treatment response in cancer models
Author(s): Prakash Rai; Sung K. Chang; Zhiming Mai; Daniel Neuman; Tayyaba Hasan
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Paper Abstract

Pancreatic cancer (PanCa) has a poor prognosis with a 5-year survival rate of only 5%. Photodynamic therapy (PDT) has shown promising results in treating PanCa. Mechanism-based combinations with PDT have enhanced treatment outcome. Agents tested with PDT include Avastin, an antibody against vascular endothelial growth factor (VEGF) which is approved for treating various cancers. Simultaneous delivery of drugs in nano-constructs could improve the treatment response of mechanism based combination therapies. Here, we investigate the effect of neutralizing VEGF using nanotechnology for the delivery of Avastin in combination with PDT. For this we used a construct called "nanocells" in which the photosensitizer was trapped inside polymer nanoparticles and these, with Avastin, were then encapsulated inside liposomes. In vitro, nanocells containing Avastin (NCA) significantly enhanced cytotoxicity in PanCa cells. NCA based PDT also significantly improved treatment response in mice that were orthotopically implanted with PanCa. Avastin delivered extracellularly in combination with PDT did not show any improvement. Here we propose a new paradigm for Avastin-based therapy by combining intracellular delivery of the antibody and PDT using nanotechnology for treating PanCa.

Paper Details

Date Published: 13 July 2009
PDF: 11 pages
Proc. SPIE 7380, Photodynamic Therapy: Back to the Future, 73800W (13 July 2009); doi: 10.1117/12.828402
Show Author Affiliations
Prakash Rai, Wellman Ctr. for Photomedicine, MGH (United States)
Sung K. Chang, Wellman Ctr. for Photomedicine, MGH (United States)
Zhiming Mai, Wellman Ctr. for Photomedicine, MGH (United States)
Daniel Neuman, Wellman Ctr. for Photomedicine, MGH (United States)
Tayyaba Hasan, Wellman Ctr. for Photomedicine, MGH (United States)

Published in SPIE Proceedings Vol. 7380:
Photodynamic Therapy: Back to the Future
David H. Kessel, Editor(s)

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