Share Email Print
cover

Proceedings Paper

Exploiting bacterial drug resistance: a single construct for the diagnosis and treatment of drug resistant infections
Author(s): Ulysses W. Sallum; Xiang Zheng; Sarika Verma; Tayyaba Hasan
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

β-lactamase enzyme-activated photosensitizer (β-LEAP). We aim to exploit drug resistance mechanisms to selectively release photosensitizers (PSs) for a specific photodynamic antimicrobial effect and reduced host tissue damage. Consequently, the fluorescence emission intensity of the PSs increases and allows for the detection of enzyme activity. In this work we sought to evaluate β-LEAP for use as a sensitive molecular probe. We have reported the enzyme specific antibacterial action of β-LEAP. Here we report the use of β-LEAP for the rapid functional definition of a β-lactamase.

Paper Details

Date Published: 13 July 2009
PDF: 9 pages
Proc. SPIE 7380, Photodynamic Therapy: Back to the Future, 73806R (13 July 2009); doi: 10.1117/12.828202
Show Author Affiliations
Ulysses W. Sallum, Wellman Ctr. for Photomedicine, MGH (United States)
Harvard Medical School (United States)
Xiang Zheng, Wellman Ctr. for Photomedicine, MGH (United States)
Harvard Medical School (United States)
Sarika Verma, Wellman Ctr. for Photomedicine, MGH (United States)
Harvard Medical School (United States)
Tayyaba Hasan, Wellman Ctr. for Photomedicine, MGH (United States)
Harvard Medical School (United States)


Published in SPIE Proceedings Vol. 7380:
Photodynamic Therapy: Back to the Future

© SPIE. Terms of Use
Back to Top