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Proceedings Paper

OLED-based biosensing platform with ZnO nanoparticles for enzyme immobilization
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Paper Abstract

Organic light-emitting diode (OLED)-based sensing platforms are attractive for photoluminescence (PL)-based monitoring of a variety of analytes. Among the promising OLED attributes for sensing applications is the thin and flexible size and design of the OLED pixel array that is used for PL excitation. To generate a compact, fielddeployable sensor, other major sensor components, such as the sensing probe and the photodetector, in addition to the thin excitation source, should be compact. To this end, the OLED-based sensing platform was tested with composite thin biosensing films, where oxidase enzymes were immobilized on ZnO nanoparticles, rather than dissolved in solution, to generate a more compact device. The analytes tested, glucose, cholesterol, and lactate, were monitored by following their oxidation reactions in the presence of oxygen and their respective oxidase enzymes. During such reactions, oxygen is consumed and its residual concentration, which is determined by the initial concentration of the above-mentioned analytes, is monitored. The sensors utilized the oxygen-sensitive dye Pt octaethylporphyrin, embedded in polystyrene. The enzymes were sandwiched between two thin ZnO layers, an approach that was found to improve the stability of the sensing probes.

Paper Details

Date Published: 21 August 2009
PDF: 8 pages
Proc. SPIE 7418, Organic Semiconductors in Sensors and Bioelectronics II, 74180R (21 August 2009); doi: 10.1117/12.828201
Show Author Affiliations
Yuankun Cai, Ames Lab. and Iowa State Univ. (United States)
Ruth Shinar, Ames Lab. and Iowa State Univ. (United States)
Joseph Shinar, Ames Lab. and Iowa State Univ. (United States)

Published in SPIE Proceedings Vol. 7418:
Organic Semiconductors in Sensors and Bioelectronics II
Ruth Shinar; George G. Malliaras, Editor(s)

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