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Proceedings Paper

Glucose sensing using 3D array of reproducible surface enhanced Raman scattering substrates
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Paper Abstract

Surface Enhanced Raman Scattering (SERS) technique is used as an indispensable and sensitive modality for bio-sensing due to its ability to distinguish the analyte molecules based on their distinct 'fingerprint' spectra. One of the most promising SERS substrates for biosensing was fabricated by coating noble metal film over orderly packed nanospheres. However, the major challenge in developing such a sensor is to achieve reproducible SERS substrate. Here, we report a new class of SERS substrate with ordered 3D nanostructures fabricated on silicon wafer by deep UV lithography technique followed by bi-metallic coating of silver and gold. Compared to the substrate fabricated by conventional nanosphere lithography, this approach allows better control of the nanostructures, which in turn gives uniform surface roughness for the metal film to provide adequate SERS enhancement with high reproducibility. Significance of this substrate for biomedical application was demonstrated by glucose sensing under physiologically relevant conditions. Partitioning and localization of glucose molecules within the first few nanometers of active SERS substrate was achieved by a self assembled monolayer (SAM) on the surface of substrate.

Paper Details

Date Published: 21 August 2009
PDF: 10 pages
Proc. SPIE 7397, Biosensing II, 73970C (21 August 2009); doi: 10.1117/12.827228
Show Author Affiliations
Dinish U. S, Singapore Bioimaging Consortium (Singapore)
Chit Yaw Fu, Singapore Bioimaging Consortium (Singapore)
Ajay Agarwal, Institute of Microelectronics (Singapore)
Praveen Thoniyot, Singapore Bioimaging Consortium (Singapore)
Malini Olivo, Singapore Bioimaging Consortium (Singapore)
National Cancer Ctr. Singapore (Singapore)
National Univ. of Singapore (Singapore)

Published in SPIE Proceedings Vol. 7397:
Biosensing II
Manijeh Razeghi; Hooman Mohseni, Editor(s)

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