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Proceedings Paper

Photochemistry-based immune modulation in the treatment of cutaneous leishmaniasis
Author(s): Oleg E Akilov; Sachiko Kosaka; Tayyaba Hasan
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Paper Abstract

The destruction of infectious pathogens by photodynamic therapy (PDT) is an emerging modality. We demonstrated the efficacy of PDT for the management of cutaneous leishmaniasis in our previous studies. However, much remains to be done for the improvement of PDT regimens. The modulation of the immune response by photochemistry is an exciting but under-explored area of PDT research. The goal of this study is to understand the mechanisms of the augmentation of the host immune response after PDT of cutaneous leishmaniasis (CL). We found that PDT with phenoxiazine analogues was capable for induction of Th1 immune response due to stimulation of IL- 12 production by dendritic cells. Single PDT treatment facilitated fast healing of the CL lesions due to effective parasite eradication and augmentation of the immune system. Comparative study with different photosensitizers (PS) (porphyrins, pehnoxiazines) demonstrated different immunomodulating properties of PDT depending on chemical class of PS. Knowing the particular profiles and immunomodulating properties of the pertinent PSs allows us to select the optimal PS with regards to both the photodestructive and immunostimulating potential.

Paper Details

Date Published: 13 July 2009
PDF: 10 pages
Proc. SPIE 7380, Photodynamic Therapy: Back to the Future, 73803G (13 July 2009); doi: 10.1117/12.827041
Show Author Affiliations
Oleg E Akilov, Wellman Center for Photomedicine, MGH (United States)
Harvard Medical School (United States)
Sachiko Kosaka, Wellman Center for Photomedicine, MGH (United States)
Harvard Medical School (United States)
Tayyaba Hasan, Wellman Center for Photomedicine, MGH (United States)
Harvard Medical School (United States)


Published in SPIE Proceedings Vol. 7380:
Photodynamic Therapy: Back to the Future
David H. Kessel, Editor(s)

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