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Proceedings Paper

Chemiluminescent solid lipid nanoparticles (SLN) and interations with intact skin
Author(s): Jennifer Breidenich; Julia Patrone; Lisa Kelly; Jason Benkoski; Huong Le; Jennifer Sample
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Paper Abstract

We report the synthesis and characterization of a novel nanoparticle formulation designed for skin penetration for the purpose of skin imaging. Solid lipid nanoparticles (SLNs), a drug delivery vehicle, were used as the matrix for targeted delivery of peroxide-sensitive chemiluminescent compounds to the epidermis. Luminol and oxalate were chosen as the chemiluminescent test systems, and a formulation was determined based upon non-toxic components, lotion-like properties, and longevity/visibility of a chemiluminescent signal. The luminescence lifetime was extended in the lipid formulation in comparison to the chemiluminescent system in solution. When applied to porcine skin, our formulation remained detectable relative to negative and positive controls. Initial MTT toxicity testing using HepG2 cells have indicated that this formulation is relatively non-toxic. This formulation could be used to image native peroxides present in tissue that may be indicative of skin disease.

Paper Details

Date Published: 24 August 2009
PDF: 10 pages
Proc. SPIE 7397, Biosensing II, 73970L (24 August 2009); doi: 10.1117/12.826397
Show Author Affiliations
Jennifer Breidenich, The Johns Hopkins Univ. Applied Physics Lab. (United States)
Julia Patrone, The Johns Hopkins Univ. Applied Physics Lab. (United States)
Lisa Kelly, The Johns Hopkins Univ. Applied Physics Lab. (United States)
Jason Benkoski, The Johns Hopkins Univ. Applied Physics Lab. (United States)
Huong Le, The Johns Hopkins Univ. Applied Physics Lab. (United States)
Jennifer Sample, The Johns Hopkins Univ. Applied Physics Lab. (United States)


Published in SPIE Proceedings Vol. 7397:
Biosensing II
Manijeh Razeghi; Hooman Mohseni, Editor(s)

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