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Proceedings Paper

Multimodal plasmonic nanosensor for the detection of pathogenic bacteria
Author(s): Li-Lin Tay; John Hulse; Shannon Ryan; Jamshid Tanha; Jeff Fraser; Xiaohua Wu
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Paper Abstract

Multi-modal sensing scheme significantly improves the detection accuracy but can also introduce extra complexity in the overall design of the sensor. We overcome this difficulty by utilizing the plasmonic properties of metallic nanoparticles. In this study, we will present a simple dual optical sensing mechanism which harvests signals of the resonantly excited metallic nanostructure in the form of surface enhanced Raman scattering (SERS) and resonant Rayleigh scattering. Silver and gold nanoparticles labeled with appropriate antibodies act as signal transduction units and upon exposure to the targeted pathogen render the targeted species optically active. We demonstrate that detection of a single pathogen cell is easily attainable with the dual detection scheme. Furthermore, we explore the markedly different SERS intensity observed from the use of two very different antibody recognition units during the pathogen labeling process.

Paper Details

Date Published: 25 August 2009
PDF: 9 pages
Proc. SPIE 7397, Biosensing II, 73970B (25 August 2009); doi: 10.1117/12.826093
Show Author Affiliations
Li-Lin Tay, National Research Council Canada (Canada)
John Hulse, National Research Council Canada (Canada)
Shannon Ryan, National Research Council Canada (Canada)
Jamshid Tanha, National Research Council Canada (Canada)
Jeff Fraser, National Research Council Canada (Canada)
Xiaohua Wu, National Research Council Canada (Canada)

Published in SPIE Proceedings Vol. 7397:
Biosensing II
Manijeh Razeghi; Hooman Mohseni, Editor(s)

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