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Proceedings Paper

Selenium enhances the efficacy of Radachlorin-mediated photodynamic therapy in cervical cancer model
Author(s): Dong Han Bae; Lan Ying Wen; Su Mi Bae; Uk Kang; Keun Hee Kim; Sang Hoon Jheon; Jeong Sang Lee; Woong Shick Ahn
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Paper Abstract

Selenium, an essential trace element possessing anti-carcinogenic properties, can induce apoptosis in cancer cells. Our goal was to investigate the enhanced anti-tumor effects of photodynamic therapy (PDT) plus selenium in TC-1 tumor cells implanted into mice. The MTT assay and tumor growth inhibition study were evaluated at various time intervals after the PDT plus a various dose of selenium. Following Radachlorin injections after 3 hr, the mice were then administrated selenium (2ug/kg b.w.) and then, tumors were treated with external light treatment (300 J/cm2). The selenium was administered daily for 20 days. PDT or selenium was found to be more compared to control groups. Moreover, the PDT combined with selenium demonstrated a significant suppression of tumor growth in vitro and in vivo. The tumor growth by the PDT combined with selenium was significantly reduced. These data suggest that selenium plus PDT can induce a significant tumor suppression response compared with PDT alone. Also, it can be an effective approach to induce anti-cancer therapy strategy.

Paper Details

Date Published: 13 July 2009
PDF: 10 pages
Proc. SPIE 7380, Photodynamic Therapy: Back to the Future, 73802T (13 July 2009); doi: 10.1117/12.824242
Show Author Affiliations
Dong Han Bae, Soonchunhyang Univ. (Korea, Republic of)
Lan Ying Wen, The Catholic Univ. of Korea (Korea, Republic of)
Su Mi Bae, The Catholic Univ. of Korea (Korea, Republic of)
Uk Kang, Korea Electrotechnology Research Institute (Korea, Republic of)
Keun Hee Kim, Korea Electrotechnology Research Institute (Korea, Republic of)
Sang Hoon Jheon, Seoul National Univ. Hospital (Korea, Republic of)
Jeong Sang Lee, Seoul National Univ. Hospital (Korea, Republic of)
Woong Shick Ahn, The Catholic Univ. of Korea (Korea, Republic of)


Published in SPIE Proceedings Vol. 7380:
Photodynamic Therapy: Back to the Future
David H. Kessel, Editor(s)

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