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Proceedings Paper

Photodynamic effects of Photodithazine on cervical cancer model
Author(s): Sei Jun Han; Lan Ying Wen; Su Mi Bae; Young-Seon Hong; Hong-Seok Jang; Jeong Whan Lee; Woong Shick Ahn
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Paper Abstract

Photodynamic therapy (PDT) has been reported to be effective for treating various tumors and induce apoptosis in many tumor cells. In this study, we examined a biological significance of PDT with a new photosensitizer, Photodithazine, in a cervical cancer model using TC-1 cells. Also, to see the accumulation level of Photodithazine in tumours, we measured the concentration of Photodithazine at indicated time points in tumours of the mice injected with Photodithazine. When the tumor bearing mice were exposed to varied doses of Photodithazine with laser irradiation (300 J/cm2), retarded tumor growth was significant in mice treated with PDT, as compared to the control group. On the other hand, in the uptake of Photodithazine experiments showed that the highest accumulation of Photodithazine in tumors was shown at 0·5 hr after injection and its concentration was decreased. Photodithazine keeps high concentration values during the first day, Photodithazine showed a rapid clearance from sera as it is relatively long kept by tumor tissue. Taken together, we propose that PDT after the application of Photodithazine may be effective in the mice system.

Paper Details

Date Published: 13 July 2009
PDF: 7 pages
Proc. SPIE 7380, Photodynamic Therapy: Back to the Future, 73805Z (13 July 2009); doi: 10.1117/12.824241
Show Author Affiliations
Sei Jun Han, Chosun Univ. (Korea, Republic of)
Lan Ying Wen, The Catholic Univ. of Korea (Korea, Republic of)
Su Mi Bae, The Catholic Univ. of Korea (Korea, Republic of)
Young-Seon Hong, The Catholic Univ. of Korea (Korea, Republic of)
Hong-Seok Jang, The Catholic Univ. of Korea (Korea, Republic of)
Jeong Whan Lee, Diatech Korea Co., Ltd. (Korea, Republic of)
Woong Shick Ahn, The Catholic Univ. of Korea (Korea, Republic of)

Published in SPIE Proceedings Vol. 7380:
Photodynamic Therapy: Back to the Future
David H. Kessel, Editor(s)

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