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Proceedings Paper

New porphyrin glyco-conjugates
Author(s): Charles Michael Drain; Sunaina Singh; Diana Samaroo; Sebastian Thompson; Mikki Vinodu; Joao P. C. Tome
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Paper Abstract

Porphyrins bearing sugars and other motifs are proposed for a variety of therapeutic applications. Non-hydrolysable glyco conjugates of porphyrins can be formed in rapid, room temperature reacting in greater than 90% yields from tetraperfluorophenyporphyrin. Additional functional groups can be appended using the same chemistry but different stoichiometries of the reagents. Thus sugars, amines, peptides, and cationic moieties designed to target cancer cells or other diseased or disease-causing cells are made rapidly and cleanly. These compounds can then be rapidly screened for cell uptake, or selected from combinatorial libraries by cell uptake assays using a combination of fluorescence microscopy and mass spectrometry. Modifications of the macrocycle allow fine-tuning of the photonic properties for specific medical, imaging, or biochemical applications.

Paper Details

Date Published: 13 July 2009
PDF: 9 pages
Proc. SPIE 7380, Photodynamic Therapy: Back to the Future, 73802K (13 July 2009); doi: 10.1117/12.823855
Show Author Affiliations
Charles Michael Drain, Hunter College of CUNY (United States)
The Rockefeller Univ. (United States)
Sunaina Singh, Hunter College of CUNY (United States)
Diana Samaroo, Hunter College of CUNY (United States)
Sebastian Thompson, Hunter College of CUNY (United States)
Mikki Vinodu, Hunter College of CUNY (United States)
Joao P. C. Tome, Hunter College of CUNY (United States)

Published in SPIE Proceedings Vol. 7380:
Photodynamic Therapy: Back to the Future
David H. Kessel, Editor(s)

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