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Proceedings Paper

Meta-analysis of five photodisinfection clinical trials for periodontitis
Author(s): Roger C. Andersen; Nicolas G. Loebel; Dane M. Andersen
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Paper Abstract

Photodynamic therapy(PDT) has been demonstrated to effectively kill human periopathogens in vitro. To evaluate the efficacy of PDT in vivo a series of clinical trials was carried out in multiple centers and populations. Clinical parameters including clinical attachment level, pocket probing depth and bleeding on probing were all evaluated. All groups received the standard of care, scaling and root planing, and the treatment group additionally received a single treatment of PDT. Of the total 309 patients and over 40,000 pockets treated in these 5 trials it was determined that photodynamic therapy provided a statistically significant improvement in clinical parameters over scaling and root planing alone.

Paper Details

Date Published: 13 July 2009
PDF: 11 pages
Proc. SPIE 7380, Photodynamic Therapy: Back to the Future, 73804K (13 July 2009); doi: 10.1117/12.823567
Show Author Affiliations
Roger C. Andersen, Ondine Research Labs., Inc. (United States)
Nicolas G. Loebel, Ondine Research Labs., Inc. (United States)
Dane M. Andersen, Loma Linda Univ. (United States)


Published in SPIE Proceedings Vol. 7380:
Photodynamic Therapy: Back to the Future
David H. Kessel, Editor(s)

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