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Proceedings Paper

Treatment of vulvar/vaginal condyloma by HPV: developed instrumentation and clinical report
Author(s): N. M. Inada; C. Kurachi; J. Ferreira; E. S. Ribeiro; O. C. C. Guimarães; S. M. Quintana; W. Lombardi; V. S. Bagnato
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Paper Abstract

Human papillomavirus (HPVs) are a family of sexually viruses with over 100 different genotypes identified till date. They are associated in 99% of cervical cancers, with HPV16 found in about 50% of cases. They are a cause of the second most common female cancer worldwide. PDT may constitute an alternative treatment for condyloma by HPV. In this work we present the development of a PDT device specifically designed for the treatment of vulvar and vaginal lesions induced by HPV. This equipment has been used in a clinical protocol and it is optically based on 640 nm LED (light emitting diodes) arrays. There are three illumination probes available that were anatomically designed for specific site applications: a 30 mm x 115 mm diffuser cylinder for intravaginal illumination and uniform irradiance of 42 mW/cm2; a 36 mm circular probe with 118 mW/cm2 and a 74 mm circular probe with 57 mW/cm2, both for external illumination. The 10% aminolevulinic acid cream is topically placed over the lesions and 4-6 hours after the application the illumination is performed. The illumination time is set depending on the chosen probe and treatment area to achieve a fluence of 200 J/cm2. In this presentation, the preliminary results of this clinical trial will be presented.

Paper Details

Date Published: 13 July 2009
PDF: 9 pages
Proc. SPIE 7380, Photodynamic Therapy: Back to the Future, 738054 (13 July 2009); doi: 10.1117/12.823034
Show Author Affiliations
N. M. Inada, Univ. de São Paulo (Brazil)
C. Kurachi, Univ. de São Paulo (Brazil)
J. Ferreira, Univ. de São Paulo (Brazil)
E. S. Ribeiro, Univ. de São Paulo (Brazil)
O. C. C. Guimarães, Univ. de São Paulo (Brazil)
S. M. Quintana, Univ. de São Paulo (Brazil)
W. Lombardi, UNIARA (Brazil)
V. S. Bagnato, Univ. de São Paulo (Brazil)

Published in SPIE Proceedings Vol. 7380:
Photodynamic Therapy: Back to the Future
David H. Kessel, Editor(s)

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