Share Email Print
cover

Proceedings Paper

Effectiveness in total reduction of Candida albicans promoted by PDT with hypocrellin B:lanthanum
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

In this work we described the potentiality of the Hypocrellin B (HB) modified with the presence of lanthanum (La3+) ions, in eliminate Candida albicans in suspension. The results showed that the presence of lanthanum ions promotes a red shift of the HB absorption band and an enhancement in singlet oxygen quantum yield in 32%. Also in this work we obtained that the best molar ration between HB and La concentrations was 1:2. No photobleaching was observed in our experimental conditions. Antimicrobial activity was studied exciting C. albicans suspension with a 460 nm LED and a 660 nm laser both with 330 mW/cm2 irradiance. Best irradiation time, PS concentration and ROS production profile were determined showing that using 460 nm LED with 10 μM of PS, only 30 s of irradiation time was sufficient to reduce 100 % C. albicans colonies.

Paper Details

Date Published: 13 July 2009
PDF: 10 pages
Proc. SPIE 7380, Photodynamic Therapy: Back to the Future, 738060 (13 July 2009); doi: 10.1117/12.823013
Show Author Affiliations
Daniel J. Tofolli, Instituto de Pesquisas Energéticas e Nucleares (Brazil)
Renato A. Prates, Instituto de Pesquisas Energéticas e Nucleares (Brazil)
Martha S. Ribeiro, Instituto de Pesquisas Energéticas e Nucleares (Brazil)
Nilson D. Vieira, Instituto de Pesquisas Energéticas e Nucleares (Brazil)
M. C. E. Hashimoto, Instituto de Pesquisas Energéticas e Nucleares (Brazil)
Lilia C. Courrol, Univ. Federal de São Paulo (Brazil)


Published in SPIE Proceedings Vol. 7380:
Photodynamic Therapy: Back to the Future
David H. Kessel, Editor(s)

© SPIE. Terms of Use
Back to Top