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Proceedings Paper

Comparative in vivo study of precursors of PpIX (ALA and MAL) used topically in photodynamic therapy
Author(s): Raquel Ferreira Rego; Natalia Mayumi Inada; Juliana Ferreira; Fernando Manuel Araújo-Moreira; Vanderlei Salvador Bagnato
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Paper Abstract

The efficacy of Photodynamic Therapy (PDT) combined with aminolevulinic acid (ALA) or methyl aminolevulinate (MAL) in treatment of cancer has been studied for over ten years. However, there is no established dose for the topical use of these drugs in PDT. The purpose of this study was the comparison of induced PDT response of ALAsense (5-aminolevulinic acid - ALA) and Metvix (methyl aminolevulinate - MAL). Depth of necrosis induced by PDT was analyzed in normal liver of male Wistar rats, using different light doses and topical application of both PpIX precursors - ALA and MAL. PDT was performed with a diode laser at 630 nm with different doses of light (20, 50, 100 and 200 J/cm2), and intensity of 250 mW/cm2. Depth of necrosis analysis was used to calculate the threshold dose for each drug. The results showed that MAL-PDT presented a better response than ALA-PDT, mainly due to formulation differences. Moreover, the ability of the ALA PpIX production was more efficient.

Paper Details

Date Published: 13 July 2009
PDF: 12 pages
Proc. SPIE 7380, Photodynamic Therapy: Back to the Future, 73805I (13 July 2009); doi: 10.1117/12.823012
Show Author Affiliations
Raquel Ferreira Rego, Univ. Federal de São Carlos (Brazil)
Natalia Mayumi Inada, Univ. de São Paulo (Brazil)
Juliana Ferreira, Univ. de São Paulo (Brazil)
Fernando Manuel Araújo-Moreira, Univ. Federal de São Carlos (Brazil)
Vanderlei Salvador Bagnato, Univ. de São Paulo (Brazil)

Published in SPIE Proceedings Vol. 7380:
Photodynamic Therapy: Back to the Future
David H. Kessel, Editor(s)

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