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Proceedings Paper

New pain-relieving strategies for topical photodynamic therapy
Author(s): Christina B. Halldin; John Paoli; Carin Sandberg; Marica B. Ericson; Helena Gonzalez; Ann-Marie Wennberg
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Paper Abstract

PDT is an effective method when treating multiple actinic keratoses (field cancerization). The major side effect is pain. Our objectives were to investigate the pain-relieving effect of transcutaneous electrical nerve stimulation (TENS) and peripheral nerve blocks during PDT of field cancerization (FC) of the face and scalp. Patients with field cancerization were included in three studies. In the first study, we examined TENS with an application site on the adjacent dermatome from the PDT area in order to allow the use of water spray during PDT for FC of the scalp and face. In the second study, patients with FC in the facial area received unilateral supraorbital, infraorbital and/or mental nerve blocks. The non-anaesthetised side of the treatment area served as control. In the third study, with similar methodology as in the second study, occipital and supraorbital nerve blocks were combined for FC of the forehead and scalp. The results of the studies strongly support the use of nerve blocks as pain relief during PDT. The use of TENS provided a limited pain reduction, but TENS might be an alternative if the patient disapproves of the use of nerve blocks or is afraid of injections.

Paper Details

Date Published: 13 July 2009
PDF: 13 pages
Proc. SPIE 7380, Photodynamic Therapy: Back to the Future, 73801O (13 July 2009); doi: 10.1117/12.822988
Show Author Affiliations
Christina B. Halldin, Sahlgrenska Univ. Hospital-Univ. of Gothenburg (Sweden)
John Paoli, Sahlgrenska Univ. Hospital-Univ. of Gothenburg (Sweden)
Carin Sandberg, Sahlgrenska Univ. Hospital-Univ. of Gothenburg (Sweden)
Marica B. Ericson, Sahlgrenska Univ. Hospital-Univ. of Gothenburg (Sweden)
Helena Gonzalez, Sahlgrenska Univ. Hospital-Univ. of Gothenburg (Sweden)
Ann-Marie Wennberg, Sahlgrenska Univ. Hospital-Univ. of Gothenburg (Sweden)


Published in SPIE Proceedings Vol. 7380:
Photodynamic Therapy: Back to the Future
David H. Kessel, Editor(s)

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