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Proceedings Paper

Development of novel bifunctional agents with and without tumor imaging ability
Author(s): Manivannan Ethirajan; Michael Williams; Norm Angelino; Joseph R. Missert; Ravindra K. Pandey
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Paper Abstract

Purpurinimides, derived from chlorophyll-a, are tumor avid, stable in vivo and show a strong absorption in the near IR region (700 nm) with a high singlet oxygen (>50%) producing efficiency. Such a characteristic could be useful in treating large and deeply seated tumors by photodynamic therapy (PDT). These long wavelength photosensitizers can be used as vehicles to deliver the imaging agents to tumors. Therefore, by linking suitable tumor imaging moiety with purpurinimide could produce a novel bifunctional agent, which could possess the desired photo physical properties for both tumor detection as well as photodynamic therapy. Such image guided therapy would represent an archetype for cancer treatment.

Paper Details

Date Published: 13 July 2009
PDF: 11 pages
Proc. SPIE 7380, Photodynamic Therapy: Back to the Future, 73806K (13 July 2009); doi: 10.1117/12.822987
Show Author Affiliations
Manivannan Ethirajan, Roswell Park Cancer Institute (United States)
Michael Williams, Roswell Park Cancer Institute (United States)
Norm Angelino, Roswell Park Cancer Institute (United States)
Joseph R. Missert, Roswell Park Cancer Institute (United States)
Ravindra K. Pandey, Roswell Park Cancer Institute (United States)


Published in SPIE Proceedings Vol. 7380:
Photodynamic Therapy: Back to the Future

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