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Proceedings Paper

Reconstruction of hemodynamics and sensitizer distributions during interstitial PDT using spectroscopy with linear light sources
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Paper Abstract

Light dosimetry for photodynamic therapy requires a knowledge of the optical absorption spectrum of the tissue being treated Here, we present a theoretical and experimental analysis of the capabilities of a system using interstitial linear light sources ranging in length from 2 to 5 cm to illuminate the tissue interstitially, and isotropic point-like detectors to measure the resulting diffusely transmitted light. The sources and detectors are translated in transparent plastic catheters under the control of a motorized positioning system designed for interstitial measurements in the prostate. The light source is a quartz-tungsten-halogen (QTH), and the spectrally resolved detection is accomplished using a CCD-based grating spectrometer. The data are analyzed using an approximation to the radiative transport equation, assuming homogeneous scattering and heterogeneous absorption spectra Absorption spectra are reconstructed independently for individual source-detector channel pairs. Sequential reconstruction can then be used to create a 3-dimensional reconstruction. The results of simulated data, measurements made in multi-component phantoms, and synthetic data reconstructed from in vivo measurements made with point sources demonstrate the feasibility of this method.

Paper Details

Date Published: 13 July 2009
PDF: 8 pages
Proc. SPIE 7380, Photodynamic Therapy: Back to the Future, 738044 (13 July 2009); doi: 10.1117/12.822964
Show Author Affiliations
Jarod C. Finlay, Univ. of Pennsylvania (United States)
Ken Wang, Univ. of Pennsylvania (United States)
Yida Hu, Univ. of Pennsylvania (United States)
Timothy C. Zhu, Univ. of Pennsylvania (United States)

Published in SPIE Proceedings Vol. 7380:
Photodynamic Therapy: Back to the Future
David H. Kessel, Editor(s)

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