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Proceedings Paper

Burn, freeze, or photo-ablate?: comparative symptom profile in Barrett's dysplasia patients undergoing endoscopic ablation
Author(s): Kanwar Rupinder S. Gill; Seth A. Gross; Bruce D. Greenwald; Lois L. Hemminger; Herbert C. Wolfsen
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Paper Abstract

Background: There are few data available comparing endoscopic ablation methods for Barrett's esophagus with high-grade dysplasia (BE-HGD). Objective: To determine differences in symptoms and complications associated with endoscopic ablation. Design: Prospective observational study. Setting: Two tertiary care centers in USA. Patients: Consecutive patients with BE-HGD Interventions: In this pilot study, symptoms profile data were collected for BE-HGD patients among 3 endoscopic ablation methods: porfimer sodium photodynamic therapy, radiofrequency ablation and low-pressure liquid nitrogen spray cryotherapy. Main Outcome Measurements: Symptom profiles and complications from the procedures were assessed 1-8 weeks after treatment. Results: Ten BE-HGD patients were treated with each ablation modality (30 patients total; 25 men, median age: 69 years (range 53-81). All procedures were performed in the clinic setting and none required subsequent hospitalization. The most common symptoms among all therapies were chest pain, dysphagia and odynophagia. More patients (n=8) in the porfimer sodium photodynamic therapy group reported weight loss compared to radio-frequency ablactation (n=2) and cryotherapy (n=0). Four patients in the porfimer sodium photodynamic therapy group developed phototoxicity requiring medical treatment. Strictures, each requiring a single dilation, were found in radiofrequency ablactation (n=1) and porfimer sodium photodynamic therapy (n=2) patients. Limitations: Small sample size, non-randomized study. Conclusions: These three endoscopic therapies are associated with different types and severity of post-ablation symptoms and complications.

Paper Details

Date Published: 13 July 2009
PDF: 5 pages
Proc. SPIE 7380, Photodynamic Therapy: Back to the Future, 73804J (13 July 2009); doi: 10.1117/12.822827
Show Author Affiliations
Kanwar Rupinder S. Gill, Mayo Clinic (United States)
Seth A. Gross, Norwalk Hospital (United States)
Bruce D. Greenwald, Univ. of Maryland School of Medicine (United States)
Lois L. Hemminger, Mayo Clinic (United States)
Herbert C. Wolfsen, Mayo Clinic (United States)


Published in SPIE Proceedings Vol. 7380:
Photodynamic Therapy: Back to the Future

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