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Proceedings Paper

Topical application of ALA PDT for the treatment of moderate to severe acne vulgaris
Author(s): Xiu-Li Wang; Hong-Wei Wang; Ling-Lin Zhang; Lina Su; Ming-Xia Guo; Zheng Huang
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Paper Abstract

Objectives: To evaluate the effectiveness of topical 5-aminolevulinic acid (ALA)- medicated photodynamic therapy (ALA PDT) for the treatment of moderate to severe acne vulgaris. Methods: Sixteen Chinese patients with moderate to severe facial acne were treated with 1-3 courses of ALA PDT. ALA cream (3%) was freshly prepared and applied to acne lesions for 3-4 h. The lesions were irradiated by a 635 nm diode laser at dose levels of 60 - 80 J/cm2 at 100 mW/cm2. Clinical assessments were conducted before and after treatment up to 3 months. Results: All patents showed response to ALA PDT. Complete clearance was seen in 10 patients (62.5%) and partial clearance in 6 patients (37.5%). One case showed recurrence after complete clearance at 2 months and another two showed recurrence after complete clearance at 3 months. However, the number of new lesions were significantly reduced. Adverse effects were minimal. Conclusions: The results of this preliminary clinical study is encouraging. ALA PDT is a simple, safe and useful therapeutic option for the treatment of moderate to severe acne. Further studies to evaluate the treatment with a larger number of patients and for a longer period of follow-up are needed.

Paper Details

Date Published: 13 July 2009
PDF: 6 pages
Proc. SPIE 7380, Photodynamic Therapy: Back to the Future, 73801Z (13 July 2009); doi: 10.1117/12.822700
Show Author Affiliations
Xiu-Li Wang, Shanghai Skin Diseases and STD Hospital (China)
Hong-Wei Wang, Shanghai Skin Diseases and STD Hospital (China)
Ling-Lin Zhang, Shanghai Skin Diseases and STD Hospital (China)
Lina Su, Shanghai Skin Diseases and STD Hospital (China)
Ming-Xia Guo, Shanghai Skin Diseases and STD Hospital (China)
Zheng Huang, Shanghai Skin Diseases and STD Hospital (China)


Published in SPIE Proceedings Vol. 7380:
Photodynamic Therapy: Back to the Future
David H. Kessel, Editor(s)

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