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Proceedings Paper

Regeneration of spine disc and joint cartilages under temporal and space modulated laser radiation
Author(s): E. Sobol; A. Shekhter; A. Baskov; V. Baskov; O. Baum; I. Borchshenko; V. Golubev; A. Guller; I. Kolyshev; A. Omeltchenko; A. Sviridov; O. Zakharkina
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Paper Abstract

The effect of laser radiation on the generation of hyaline cartilage in spine disc and joints has been demonstrated. The paper considers physical processes and mechanisms of laser regeneration, presents results of investigations aimed to optimize laser settings and to develop feedback control system for laser reconstruction of spine discs. Possible mechanisms of laser-induced regeneration include: (1) Space and temporary modulated laser beam induces nonhomogeneous and pulse repetitive thermal expansion and stress in the irradiated zone of cartilage. Mechanical effect due to controllable thermal expansion of the tissue and micro and nano gas bubbles formation in the course of the moderate (up to 45-50 oC) heating of the NP activate biological cells (chondrocytes) and promote cartilage regeneration. (2) Nondestructive laser radiation leads to the formation of nano and micro-pores in cartilage matrix. That promotes water permeability and increases the feeding of biological cells. Results provide the scientific and engineering basis for the novel low-invasive laser procedures to be used in orthopedics for the treatment cartilages of spine and joints. The technology and equipment for laser reconstruction of spine discs have been tested first on animals, and then in a clinical trial. Since 2001 the laser reconstruction of intervertebral discs have been performed for 340 patients with chronic symptoms of low back or neck pain who failed to improve with non-operative care. Substantial relief of back pain was obtained in 90% of patients treated who returned to their daily activities. The experiments on reparation of the defects in articular cartilage of the porcine joints under temporal and spase modulated laser radiation have shown promising results.

Paper Details

Date Published: 23 February 2009
PDF: 7 pages
Proc. SPIE 7179, Optics in Tissue Engineering and Regenerative Medicine III, 71790B (23 February 2009); doi: 10.1117/12.822302
Show Author Affiliations
E. Sobol, Institute on Laser and Information Technologies (Russian Federation)
Arcuo Medical Inc. (United States)
A. Shekhter, Medical Academy of Moscow (Russian Federation)
Arcuo Medical Inc. (United States)
A. Baskov, Ctr. for Vertebrology and Orthopedics (Russian Federation)
Arcuo Medical Inc. (United States)
V. Baskov, Ctr. for Vertebrology and Orthopedics (Russian Federation)
O. Baum, Institute on Laser and Information Technologies (Russian Federation)
Arcuo Medical Inc. (United States)
I. Borchshenko, Ctr. for Vertebrology and Orthopedics (Russian Federation)
Arcuo Medical Inc. (United States)
V. Golubev, Ctr. for Vertebrology and Orthopedics (Russian Federation)
Arcuo Medical Inc. (United States)
A. Guller, Medical Academy of Moscow (Russian Federation)
I. Kolyshev, Medical Academy of Moscow (Russian Federation)
A. Omeltchenko, Institute on Laser and Information Technologies (Russian Federation)
Arcuo Medical Inc. (United States)
A. Sviridov, Institute on Laser and Information Technologies (Russian Federation)
Arcuo Medical Inc. (United States)
O. Zakharkina, Institute on Laser and Information Technologies (Russian Federation)
Arcuo Medical Inc. (United States)


Published in SPIE Proceedings Vol. 7179:
Optics in Tissue Engineering and Regenerative Medicine III
Sean J. Kirkpatrick; Ruikang Wang, Editor(s)

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