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Proceedings Paper

Mechanical tissue optical clearing devices: evaluation of enhanced light penetration in skin using OCT
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Paper Abstract

We report results of a study to evaluate effectiveness of a mechanical tissue optical clearing device (TOCD) using optical coherence tomography (OCT). The TOCD consists of a pin array and vacuum pressure source applied directly to the skin surface. OCT images (850 and 1310 nm) of in vivo human skin indicate an increased light penetration depth (enhanced approximately 2 fold over peripheral tissue) which spatially correlates with TOCD pin indentations. Increased contrast of the epidermal-dermal junction in OCT images spatially correlates with indented zones. OCT M-scans (time sequence of depth scans) indicate optical penetration depth monotonically increased throughout the entire image acquisition period with most improvement at early times of TOCD application with vacuum. Results of our study suggest that mechanical optical clearing of skin may provide a means to deliver increased light fluence to dermal and subdermal regions.

Paper Details

Date Published: 24 February 2009
PDF: 10 pages
Proc. SPIE 7175, Optical Interactions with Tissue and Cells XX, 71750C (24 February 2009); doi: 10.1117/12.821204
Show Author Affiliations
Christopher G. Rylander, Virginia Polytechnic Institute and State Univ. (United States)
Thomas E Milner, The University of Texas at Austin (United States)


Published in SPIE Proceedings Vol. 7175:
Optical Interactions with Tissue and Cells XX
Steven L. Jacques; E. Duco Jansen; William P. Roach, Editor(s)

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