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Proceedings Paper

A fluorescent immunoassay for the determination of procalcitonin and C-reactive protein
Author(s): F. Baldini; L. Bolzoni; A. Giannetti; G. Porro; F. Senesi; C. Trono
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Paper Abstract

The discrimination of viral and bacterial sepsis is an important issue in intensive care patients. For this purpose, the simultaneous measurements of different analytes such as C-reactive protein (CRP), procalcitonin (PCT), myeloperoxidase, interleukines and neopterin, are necessary. A novel optical platform was designed and realised for the implementation of fluorescence-based immunoassays. The core of the optical platform is a plastic biochip, formed by a series of microchannels each of them devoted to the determination of a single analyte. Sandwich assays for CRP and PCT spiked in serum were performed in order to demonstrate the reliability of a multi-array device.

Paper Details

Date Published: 18 May 2009
PDF: 8 pages
Proc. SPIE 7356, Optical Sensors 2009, 735613 (18 May 2009); doi: 10.1117/12.821005
Show Author Affiliations
F. Baldini, Institute of Applied Physics (Italy)
L. Bolzoni, Datamed S.r.L. (Italy)
A. Giannetti, Institute of Applied Physics (Italy)
G. Porro, Datamed S.r.L. (Italy)
F. Senesi, Institute of Applied Physics (Italy)
C. Trono, Institute of Applied Physics (Italy)

Published in SPIE Proceedings Vol. 7356:
Optical Sensors 2009
Francesco Baldini; Jiri Homola; Robert A. Lieberman, Editor(s)

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