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Proceedings Paper

Revealing fine microstructural morphology in the living human retina using Optical Coherence Tomography with pancorrection
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Paper Abstract

Ultra-high speed optical coherence tomography employing an ultra-broadband light source has been combined with adaptive optics utilizing a single high stroke deformable mirror and chromatic aberration compensation. The reduction of motion artefacts, geometric and chromatic aberrations (pancorrection) permits to achieve an isotropic resolution of 2-3 μm in the human eye. The performance of this non-invasive imaging modality enables to resolve cellular structures including cone photoreceptors, nerve fibre bundles and collagenous plates of the lamina cribrosa, and retinal pigment epithelial (RPE) cells in the human retina in vivo with superior detail. Alterations of cellular morphology due to cone degeneration in a colour-blind subject are investigated in ultra-high resolution with selective depth sectioning for the first time.

Paper Details

Date Published: 30 December 2008
PDF: 15 pages
Proc. SPIE 7139, 1st Canterbury Workshop on Optical Coherence Tomography and Adaptive Optics, 71390Q (30 December 2008); doi: 10.1117/12.820631
Show Author Affiliations
C. Torti, Cardiff Univ. (United Kingdom)
B. Považay, Cardiff Univ. (United Kingdom)
B. Hofer, Cardiff Univ. (United Kingdom)
A. Unterhuber, Cardiff Univ. (United Kingdom)
B. Hermann, Cardiff Univ. (United Kingdom)
W. Drexler, Cardiff Univ. (United Kingdom)

Published in SPIE Proceedings Vol. 7139:
1st Canterbury Workshop on Optical Coherence Tomography and Adaptive Optics
Adrian Podoleanu, Editor(s)

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