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Proceedings Paper

Silicates doped with luminescent ions: useful tools for optical imaging applications
Author(s): Quentin le Masne de Chermont; Cyrille Richard; Johanne Seguin; Corinne Chanéac; Michel Bessodes; Daniel Scherman
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Paper Abstract

Fluorescence is increasingly used for in vivo imaging and has provided remarkable results. Howerver this technique presents several limitations, especially due to tissue autofluorescence under external illumination and weak tissue penetration of low wavelength excitation light. We have developed an alternative optical imaging technique using persistent luminescent nanoparticles suitable for small animal imaging. These nanoparticles can be excited before the injection, and their in vivo distribution can be followed in real-time for several hours. Chemical modifications of their surface is possible leading to lung or liver targeting, or to long-lasting blood circulation.

Paper Details

Date Published: 3 March 2009
PDF: 9 pages
Proc. SPIE 7189, Colloidal Quantum Dots for Biomedical Applications IV, 71890B (3 March 2009); doi: 10.1117/12.819316
Show Author Affiliations
Quentin le Masne de Chermont, Biospace Lab. (France)
Cyrille Richard, Unité de Pharmacologie Chimique et Génétique, CNRS, ENSCP (France)
Johanne Seguin, Unité de Pharmacologie Chimique et Génétique, CNRS, ENSCP (France)
Corinne Chanéac, Lab. de Chimie de la Matière Condensée de Paris, CNRS (France)
Michel Bessodes, Unité de Pharmacologie Chimique et Génétique, CNRS, ENSCP (France)
Daniel Scherman, Unité de Pharmacologie Chimique et Génétique, CNRS, ENSCP (France)


Published in SPIE Proceedings Vol. 7189:
Colloidal Quantum Dots for Biomedical Applications IV
Marek Osinski; Thomas M. Jovin; Kenji Yamamoto, Editor(s)

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