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Proceedings Paper

Photopatternable hydrogel materials for reversible optical hydrogen peroxide and glucose sensors
Author(s): C. Pick; M. Boresi; C. Kim; D. Henthorn
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Paper Abstract

In this work, a novel photopatternable hydrogel-based material for the fluorescent detection of hydrogen peroxide was developed and studied as a possible sensing element in optical biosensors. This composite hydrogel material was developed to maximize analyte transport, be amenable to existing microfabrication techniques, and dovetail with various enzyme immobilization strategies. Nanoparticles loaded with a hydrogen peroxide sensitive europium tetracycline complex (EuTc) were mixed with monomer and crosslinker to form a photopolymerizable precursor. Sensitivity to glucose can be introduced through addition of methacrylated glucose oxidase into the precursor solution, allowing for covalent immobilization of the enzyme. As a result, the material can be integrated directly into optical biosensors for continuous glucose monitoring.

Paper Details

Date Published: 25 April 2009
PDF: 8 pages
Proc. SPIE 7313, Smart Biomedical and Physiological Sensor Technology VI, 73130A (25 April 2009); doi: 10.1117/12.818816
Show Author Affiliations
C. Pick, Missouri Univ. of Science and Technology (United States)
M. Boresi, Missouri Univ. of Science and Technology (United States)
C. Kim, Missouri Univ. of Science and Technology (United States)
D. Henthorn, Missouri Univ. of Science and Technology (United States)


Published in SPIE Proceedings Vol. 7313:
Smart Biomedical and Physiological Sensor Technology VI
Brian M. Cullum; D. Marshall Porterfield, Editor(s)

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