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Proceedings Paper

Optical stimulation in mice lacking the TRPV1 channel
Author(s): Eul Suh; Agnella Izzo Matic; Margarete Otting; Joseph T. Walsh; Claus-Peter Richter
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Paper Abstract

Lasers can be used to stimulate neural tissue, including the sciatic nerve or auditory neurons. Wells and coworkers suggested that neural tissue is likely stimulated by heat.[1,2] Ion channels that can be activated by heat are the TRPV channels, a subfamily of the Transient Receptor Potential (TRP) ion channels. TRPV channels are nonselective cation channels found in sensory neurons involved in nociception. In addition to various chemicals, TRPV channels can also be thermally stimulated. The activation temperature for the different TRPV channels varies and is 43°C for TRPV1 and 39°C for TRPV3. By performing an immunohistochemical staining procedure on frozen 20 μm cochlear slices using a primary TRPV1 antibody, we observed specific immunostaining of the spiral ganglion cells. Here we show that in mice that lack the gene for the TRPV1 channel optical radiation cannot evoke action potentials on the auditory nerve.

Paper Details

Date Published: 23 February 2009
PDF: 5 pages
Proc. SPIE 7180, Photons and Neurons, 71800S (23 February 2009); doi: 10.1117/12.816891
Show Author Affiliations
Eul Suh, Northwestern Univ. (United States)
Agnella Izzo Matic, Northwestern Univ. (United States)
Margarete Otting, Northwestern Univ. (United States)
Joseph T. Walsh, Northwestern Univ. (United States)
Claus-Peter Richter, Northwestern Univ. (United States)

Published in SPIE Proceedings Vol. 7180:
Photons and Neurons
Anita Mahadevan-Jansen; E. Duco Jansen, Editor(s)

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