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Proceedings Paper

Scintillating-nanoparticle-induced enhancement of absorbed radiation dose
Author(s): Nathan J. Withers; John B. Plumley; Nicole D. Triño; Krishnaprasad Sankar; Brian A. Akins; Antonio C. Rivera; Gennady A. Smolyakov; Graham S. Timmins; Marek Osinski
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Paper Abstract

Cerium-doped lanthanum fluoride colloidal nanocrystals offer a way to improve external radiation therapy through the enhanced absorption of high energy photons, as well as through the emission of UV light in the presence of radiation, providing a second cell killing mechanism. Lanthanum fluoride nanocrystals doped with 10% cerium were anhydrously synthesized in methanol as platelets 10-12 nm in diameter and 4-6 nm thick. The nanocrystals were characterized by transmission electron microscopy, energy dispersive spectroscopy (EDS), and by steady state UV-visible optical absorption and photoluminescence spectroscopy. Using an incoming gamma flux from a 137Cs source and a Fricke dosimeter solution to measure absorbed energy, a 55% enhancement of absorbed dose was measured for a 1.2 mg/ml loading of nanocrystals over exposure range from one to four kiloroentgens.

Paper Details

Date Published: 3 March 2009
PDF: 8 pages
Proc. SPIE 7189, Colloidal Quantum Dots for Biomedical Applications IV, 718917 (3 March 2009); doi: 10.1117/12.816628
Show Author Affiliations
Nathan J. Withers, The Univ. of New Mexico, CHTM (United States)
John B. Plumley, The Univ. of New Mexico, CHTM (United States)
Nicole D. Triño, The Univ. of New Mexico, CHTM (United States)
Krishnaprasad Sankar, The Univ. of New Mexico, CHTM (United States)
Brian A. Akins, The Univ. of New Mexico, CHTM (United States)
Antonio C. Rivera, The Univ. of New Mexico, CHTM (United States)
Gennady A. Smolyakov, The Univ. of New Mexico, CHTM (United States)
Graham S. Timmins, The Univ. of New Mexico College of Pharmacy (United States)
Marek Osinski, The Univ. of New Mexico, CHTM (United States)


Published in SPIE Proceedings Vol. 7189:
Colloidal Quantum Dots for Biomedical Applications IV
Marek Osinski; Thomas M. Jovin; Kenji Yamamoto, Editor(s)

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