Share Email Print
cover

Proceedings Paper

Role of reactive oxygen species in low level light therapy
Author(s): Aaron Chi-Hao Chen; Ying-Ying Huang; Praveen R. Arany; Michael R. Hamblin
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

This review will focus on the role of reactive oxygen species in the cellular and tissue effects of low level light therapy (LLLT). Coincidentally with the increase in electron transport and in ATP, there has also been observed by intracellular fluorescent probes and electron spin resonance an increase in intracellular reactive oxygen species (ROS) such as superoxide, hydrogen peroxide, singlet oxygen and hydroxyl radical. ROS scavengers, antioxidants and ROS quenchers block many LLLT processes. It has been proposed that light between 400-500- nm may produce ROS by a photosensitization process involving flavins, while longer wavelengths may directly produce ROS from the mitochondria. Several redox-sensitive transcription factors are known such as NF-kB and AP1, that are able to initiate transcription of genes involved in protective responses to oxidative stress. It may be the case that LLLT can be pro-oxidant in the short-term, but anti-oxidant in the long-term.

Paper Details

Date Published: 18 February 2009
PDF: 11 pages
Proc. SPIE 7165, Mechanisms for Low-Light Therapy IV, 716502 (18 February 2009); doi: 10.1117/12.814890
Show Author Affiliations
Aaron Chi-Hao Chen, Wellman Ctr. for Photomedicine, Massachusetts General Hospital (United States)
Boston Univ. School of Medicine (United States)
Ying-Ying Huang, Wellman Ctr. for Photomedicine, Massachusetts General Hospital (United States)
Harvard Medical School (United States)
Praveen R. Arany, Wellman Ctr. for Photomedicine, Massachusetts General Hospital (United States)
Harvard School of Dental Medicine (United States)
Michael R. Hamblin, Wellman Ctr. for Photomedicine, Massachusetts General Hospital (United States)
Harvard School of Dental Medicine (United States)
Harvard-MIT Division of Health Sciences and Technology (United States)


Published in SPIE Proceedings Vol. 7165:
Mechanisms for Low-Light Therapy IV
Michael R. Hamblin; Ronald W. Waynant; Juanita Anders, Editor(s)

© SPIE. Terms of Use
Back to Top