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Proceedings Paper

Towards optimization and characterization of dye-embedded gold nanoparticle clusters for multiplexed optical imaging
Author(s): M. A. McDonald; A. R. Hight Walker
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Paper Abstract

Metallic nanoparticle clusters coupling strong surface plasmons with a Raman reporter molecule have been developed for application in multiplexed optical imaging. Of interest to our work is the ability of the agents to serve as surface-enhanced Raman spectroscopy (SERS) probes. We present the seed-mediated synthesis and characterization of rhodamine B isothiocyante Au nanoparticle clusters (RhB-AuNPCs). RhB-AuNPCs are anisotropic structures which contain the Raman reporter, RhB, embedded between a gold aggregate core and gold surface layer. In contrast to typical SERS studies, the Raman signal originates from the probe (RhB-AuNPCs) and not from RhB incubated with a noble metal colloid. Characterization of the probes' optical properties is presented. The overall goal of our study is to prepare probes that may be used for the identification and spectroscopic labeling of multiple molecular biomarkers utilizing SERS imaging.

Paper Details

Date Published: 17 February 2009
PDF: 8 pages
Proc. SPIE 7192, Plasmonics in Biology and Medicine VI, 71920L (17 February 2009); doi: 10.1117/12.814779
Show Author Affiliations
M. A. McDonald, National Institute of Standards and Technology (United States)
A. R. Hight Walker, National Institute of Standards and Technology (United States)

Published in SPIE Proceedings Vol. 7192:
Plasmonics in Biology and Medicine VI
Tuan Vo-Dinh; Joseph R. Lakowicz, Editor(s)

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