Share Email Print
cover

Proceedings Paper

The effect of CT technical factors on quantification of lung fissure integrity
Author(s): D. Chong; M. S. Brown; R. Ochs; F. Abtin; M. Brown; A. Ordookhani; G. Shaw; H. J. Kim; D. Gjertson; J. G. Goldin
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

A new emphysema treatment uses endobronchial valves to perform lobar volume reduction. The degree of fissure completeness may predict treatment efficacy. This study investigated the behavior of a semiautomated algorithm for quantifying lung fissure integrity in CT with respect to reconstruction kernel and dose. Raw CT data was obtained for six asymptomatic patients from a high-risk population for lung cancer. The patients were scanned on either a Siemens Sensation 16 or 64, using a low-dose protocol of 120 kVp, 25 mAs. Images were reconstructed using kernels ranging from smooth to sharp (B10f, B30f, B50f, B70f). Research software was used to simulate an even lower-dose acquisition of 15 mAs, and images were generated at the same kernels resulting in 8 series per patient. The left major fissure was manually contoured axially at regular intervals, yielding 37 contours across all patients. These contours were read into an image analysis and pattern classification system which computed a Fissure Integrity Score (FIS) for each kernel and dose. FIS values were analyzed using a mixed-effects model with kernel and dose as fixed effects and patient as random effect to test for difference due to kernel and dose. Analysis revealed no difference in FIS between the smooth kernels (B10f, B30f) nor between sharp kernels (B50f, B70f), but there was a significant difference between the sharp and smooth groups (p = 0.020). There was no significant difference in FIS between the two low-dose reconstructions (p = 0.882). Using a cutoff of 90%, the number of incomplete fissures increased from 5 to 10 when the imaging protocol changed from B50f to B30f. Reconstruction kernel has a significant effect on quantification of fissure integrity in CT. This has potential implications when selecting patients for endobronchial valve therapy.

Paper Details

Date Published: 3 March 2009
PDF: 8 pages
Proc. SPIE 7260, Medical Imaging 2009: Computer-Aided Diagnosis, 72600Y (3 March 2009); doi: 10.1117/12.813907
Show Author Affiliations
D. Chong, Univ. of California, Los Angeles (United States)
M. S. Brown, Univ. of California, Los Angeles (United States)
R. Ochs, Univ. of California, Los Angeles (United States)
F. Abtin, Univ. of California, Los Angeles (United States)
M. Brown, Univ. of California, Los Angeles (United States)
A. Ordookhani, Univ. of California, Los Angeles (United States)
G. Shaw, Univ. of California, Los Angeles (United States)
H. J. Kim, Univ. of California, Los Angeles (United States)
D. Gjertson, Univ. of California, Los Angeles (United States)
J. G. Goldin, Univ. of California, Los Angeles (United States)


Published in SPIE Proceedings Vol. 7260:
Medical Imaging 2009: Computer-Aided Diagnosis
Nico Karssemeijer; Maryellen L. Giger, Editor(s)

© SPIE. Terms of Use
Back to Top